5 New Paid Remote Clinical Trials: Active Studies in the US

Modern technology has enabled fully remote clinical trials – studies that participants can join from home without any in-person clinic visits. Many such trials are currently recruiting across various medical conditions in the United States, often offering compensation for participants’ time and effort. Below are examples of active remote trials (with participant compensation where available), including their key details, eligibility, and registration information.

Telephone Therapy for Stress & Alcohol in HIV Patients (ACCEPT Study)

Description:
A Syracuse University pilot trial testing telephone-based Acceptance and Commitment Therapy (ACT) to reduce alcohol use and stress in people living with HIV. All study activities – four assessment calls and 4–6 therapy sessions by phone over six months – are done remotely. The trial aims to improve mental health and coping in HIV-positive individuals with risky alcohol use.
Compensation:
Up to $330 total for completing all study calls and sessions.
Eligibility:
HIV-positive adults on antiretroviral therapy, who currently consume alcohol and are willing to discuss their use. All genders, ages 18+; healthy volunteers not accepted.
NCT Number: NCT03974061 (AllClinicalTrials: https://www.allclinicaltrials.com/study/NCT03974061)

Adaptive Remote Smoking Cessation Trial (ADAPT)

Description:
A fully remote smoking cessation trial by UAB, evaluating adaptive treatment strategies for smokers who struggle to quit. Participants receive 12 weeks of free quit-medications (nicotine patches/lozenges or varenicline) mailed to their home. The study uses online surveys and phone check-ins (eight contacts over 6 months) to monitor progress. Depending on early response, treatments are adjusted (e.g. adding e-cigarettes or switching medications) to improve success. All visits and assessments are conducted remotely via phone or internet.
Compensation:
Up to $2,500 for full study completion (as reported by the UAB trial announcement). Participants receive free cessation products and may earn payments for completing surveys.
Eligibility:
Adults (21+) who smoke cigarettes daily and want to quit. Must not have serious unmanaged health issues. Healthy volunteers (non-smokers) are accepted in certain comparison groups.
NCT Number: NCT06118502 (AllClinicalTrials: https://www.allclinicaltrials.com/study/NCT06118502)

Menopause Hot-Flashes Mobile App Study

Description:
A Baylor University study testing a 5-week mobile health app for hot flash relief in menopausal women. It compares a self-guided hypnotherapy app (Evia) against a health-tracking control app. Participants use the app daily at home for 5 weeks, tracking their hot flashes and completing short surveys on symptoms and app usability. The trial is entirely online – participants enroll, use the smartphone app, and provide feedback remotely. This explores whether app-delivered hypnotherapy can significantly reduce the frequency and severity of hot flashes.
Compensation:
Participants are compensated for participation, though the exact amount is not specified (the trial listing notes compensation “varies”). All study materials (app access, etc.) are provided at no cost.
Eligibility:
Women ages 40–60 who are postmenopausal (≥1 year) and experiencing bothersome hot flashes. Must have a compatible smartphone and not be on hormone therapy. Healthy volunteers accepted (must have hot flash symptoms).
NCT Number: NCT06718803 (AllClinicalTrials: https://www.allclinicaltrials.com/study/NCT06718803)

Nationwide COVID-19 Outpatient Treatment Trial (ACTIV-6)

Description:
A decentralized COVID-19 treatment trial (ACTIV-6) testing whether repurposed oral medications can improve outcomes in mild COVID-19. Patients participate entirely from home: after a positive COVID test, eligible volunteers choose one of the study drugs (e.g. ivermectin, fluvoxamine, or others) or placebo.
The medication is shipped directly to the participant at no cost. Patients then take the study pills at home and complete brief daily online symptom surveys for 2–4 weeks, plus one follow-up survey at 90 days. There are no in-person visits – all data are collected via a secure website or phone, making it accessible nationwide.
Compensation:
Participants receive a $100 Amazon gift card upon completing the final 90-day survey. All study procedures are remote, and medications are provided for free.
Eligibility:
Adults age 30+ who tested positive for COVID-19 in the past 10 days and have at least two COVID-19 symptoms (e.g. fatigue, cough, fever). Not hospitalized; no severe underlying conditions that would contraindicate the study drugs.
NCT Number: NCT04885530 (AllClinicalTrials: https://www.allclinicaltrials.com/study/NCT04885530)

Online Single-Session Intervention for Adolescent Depression

Description:
A web-based clinical trial for adolescents (ages 11–17) with depressive symptoms, run by the Child Mind Institute. This study evaluates two brief online interventions – a “growth mindset” program and a self-compassion training – each delivered in a single 30-minute web session. Teens participate from home on a computer or tablet, completing one of the interactive sessions designed to improve mood and coping skills. There are no in-person requirements; participation is entirely online (often done in one sitting), after which youths and their parents may be asked to complete follow-up surveys remotely to track mood changes.
Compensation:
Modest compensation is typically provided for completing the program and any follow-up assessments (e.g. gift cards for survey completion), helping encourage teen and parent participation (exact amounts not publicly stated).
Eligibility:
Adolescents 11–17 years old of any gender, including those with mild to moderate depression or simply feeling very down. Parental consent is required. Healthy volunteers (teens without depression) may also join as a comparison group. A stable internet connection is needed; no in-person visits.
NCT Number: NCT04066985 (AllClinicalTrials: https://www.allclinicaltrials.com/study/NCT04066985)

Each of these trials illustrates how remote research is expanding access to diverse participants by removing geographic barriers. From telephone-delivered therapy to mailed medications with online monitoring, these studies allow people to contribute to clinical research from the comfort of home. Participants not only help advance medical knowledge but often receive expert care interventions at no cost, along with financial compensation as a thank-you for their time. If you’re interested in joining a remote trial, be sure to review the eligibility criteria and study requirements on the linked AllClinicalTrials pages, and consider reaching out to the study coordinators – you could earn some money while helping improve healthcare for all.

Sources: These trial details were compiled from clinical trial registries and official study announcements. Each AllClinicalTrials link provided leads to the registry entry for further information and contact details.